Let's use base 36! It would use the entire Latin alphabet, and would have many opf the advantages of base 12 (ie lots of easy to use fractions). And numbers would be shorter to write down, so we would save on ink and paper.
For superhumans, Heinlein ("Gulf") suggested that base 60 would be suitable. With the 60 digits also doing duty to represent the 60 phonemes of a new language, there would be 216,000 words of just three letters, most of them monosyllabic. With the speed of speech and thought this would make available, effective lifespan would be extended by many times.