[MF] The name SKELTON [the poet] springs to mind - as in 'framework' = skeleton, without the directional 'E' - but that would mean your letter clue is out of line.. Just a thought.
I've been trying some of these at thinks.com... ouch ouch ouch. If anyone knows a site with some beginner-level puzzles, I'd appreciate it. :) Anyway, this one stumped me: React badly when embraced by one scientist or another (14) -- the answer is BACTERIOLOGIST... the definition makes sense, and I understand 'react badly', but how does the rest of it fit?